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Important findings related to the birthing defects Prader-Willi Syndrome
(PWS) and Angelman Syndromes, discussed in an article released on August 25, 2008
in PLoS Biology, may help explain imprinted genes
in humans.
In
humans, two copies of each gene are contributed to a tike: one from
the mother and one from the father. Imprinted genes are genes that
express otherwise (or stop expressing) depending on whether it is
inherited from the mother or father of the child. One of the copies is
prevented from working in one of these copies, leaving the other with
all expression, which lav raise issues if the expression factor is
damaged.
These genes have not been to the full explained, only
according to the kinship theory are influenced by allocation of
maternal and paternal resources, such as nourishment or affection. Much
investigation has been performed related to the maternal contribution
to such genes, just the paternal influence has been largely neglected.
One
example of such a factor leads to a syndrome, Prader-Willi Syndrome. PWS
children get difficulty suckling after birth and mostly have a low
body weight. Once weaned from breast milk, they gain large appetites,
and they become corpulent. The Prader-Willi Syndrome Association of the
United States cites that the syndrome is found in one out of every 12
to 15 g children. While rare, it is considered the to the highest degree common
genetic cause of obesity, and is related to a damaged copy of the gene
coming from the father.
Prof. Francisco Ubeda of the
University of Tennessee, Knoxville, investigated the relationship
between this gene's expression and the amount of care tending to the
child by his sire. He as observed that PWS children experience
changes that mean near reversal of the syndrome when they obtain
significant maternal resources. Ubeda found that, as the contribution
of resources from the begetter increased, the PWS copy that is expressed
shifts. This shows that the paternal resources can have a significant
impact on imprinted genes. This relates to the typical pattern of early
human development. "Before
weaning, the mother has the monopoly on providing resources directly to
her offspring," Ubeda says."After weaning, the father directly provides
a
greater share of resources to his offspring."
Ubedo points out
that this finding testament likely not affect PWS treatment in the near
future, but it has many implications for a greater agreement of
imprinted genes. "I
don't have whatever sense that this will somehow tether to a cure for PWS, simply
it does present a new country for those interested in the disease to study
and hopefully a young understanding of how the disease functions." He
claims that the larger effects of this work may be situated in the
discovery that even a small contribution from the father early in
development tin affect expression of these genes. This new finding
answers many of the questions caused by this and similar conditions
that do non seem to be totally dictated by the mother's influence.
Evolution of genomic imprinting with biparental care:
Implications for Prader-Willi and Angelman syndromes.
Ubeda F
PLoS Biol 6(8): e208.
doi:10.1371/journal.pbio.s0060208
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Written by Anna Sophia McKenney
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Thursday 4 September 2008
Tuesday 26 August 2008
Download Stemm mp3
 Artist: Stemm: mp3 download Genre(s): Rock Discography:  Songs for the Incurable Heart Year: 2006 Tracks: 12 Affiliating the efforts of vocalist Louis Penque, Joe Cafarella (guitar, vocals), Rich Spalla (guitar), Russ Martin (bass role), and drummer Jimi Penque, all of whom take late band experience, Stemm delivers original strains inside alternative metal's most belligerent marks. Discharging creative combinations of hip-hop, rap music, and other non-mainstream styles, Stemm render away further solutions for crossbreed compositions. Forming in 1998 in Buffalo, NY, Stemm started from the very commencement of their activities to delight considerable praise inside the local medicine shot, even playing their runner establish with Sevendust. Featured on several compiling discs and on various independently released motion pictures, Stemm recorded their first magnetic disc, the EP Further Efforts, in 1999. Following a period during which their reputation continued to develop, they entered the studio over again to track record their number one record album. Dead to Me arrived in 2001, receiving positive reviews from the media and propulsive the band into new and exciting live performances. Stemm later wrote the stem strain for the Ultimate Fighting Championship ("Boldness the Pain"), hence guaranteeing their high-pressure legal would turn an integral component part of myriad pay-per-view broadcasts and extreme sporting events; their euphony canful as well be heard in various video games. The group toured and self-promoted unrelentingly scarcely about the country, and by 2004, their hard work had earned them an indorsement with Jagermeister, connexion a family of bands already including 36 Crazy Fists, Chimaira, All That Remains, and Mushroomhead, among many others. Eventually, the ring -- now comprising singer TJ Frost, guitarists Cafarella and Spalla, bassist Steve Crowl, and drummer Dan Nelligan -- hunkered grim for some other record album. The resulting Songs for the Incurable Heart was issued in September 2006 via I Scream Records. |
Saturday 16 August 2008
ZZ Top And The Black Keys To Work Together
ZZ Top are to team up with The Black Keys and may record new material together.
Apaprently the two acts were introduced by esteemed producer Rick Rubin, who is working on the veteran rocker's following album.
"I'm such a grown fan of those guys ... it makes total sense," ZZ Top guitarist Billy Gibbons told Billboard of the potential difference collaboration, "and that's pretty down and dirty, which is good for ZZ Top."
Gibbons says of his own band's new songs, he demoed 15 tracks over a 15-day-period in May, and describes the music as "everything from a black church gospel ballad to updated versions of 'Rollin' and Tumblin'."
More info
Thursday 7 August 2008
David Still Cooking on Album Release
There's a lot to be aforesaid for the company you keep, which is no doubt wherefore reigning American Idol champ David Cook has opted to team up with a Grammy-winning manufacturer for his forthcoming
Friday 27 June 2008
Cnn - Cnn Fox News Return Freebees
A report by Condé Nast's Portfolio magazine last week that both CNN
and Fox News, among other news outlets, had allowed its reporters to go on an all-expense-paid
junket to Las Vegas has resulted in the two cable networks reimbursing the expenses
to the junket's sponsors, JetBlue Airlines and the quirky local-news website Thrillist,
Portfolio reported Monday. The reporters, who were unnamed, are also being
required to return "swag bags" that included hundreds of dollars of gifts including Zune
video players. Both CNN and Fox News said that accepting invitations for such junkets
is against company policy when travel and accommodations are paid for by the sponsors.
24/06/2008
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Monday 23 June 2008
M.I.D.O.R.
Artist: M.I.D.O.R.
Genre(s):
Trance
Discography:
Groove Logic EP Volume 1
Year: 2007
Tracks: 3
Kevin Wood
Tuesday 17 June 2008
Rupa & The April Fishes, Extraordinary Rendition
San Francisco may never again capture the epiphanic heights of the 1960s, when the Haight-Ashbury intersection was the very cradle of the global countercultural movement, but it seems it's not going to give up trying.
Rupa And The April Fishes is the latest category-defying, pan-everything, all-musical-points-of-the-compass outfit to come from the melting-pot city. They're surprising and delightful, as the punningly titled debut disc Extraordinary Rendition colourfully reveals.
Extraordinary Rendition crackles with energy and seethes with vivid splashes of colour. Sung in French, Spanish and English, it has a likable ability to simultaneously stimulate and soothe, its aromatic melange of sounds throwing up surprise after surprise in a free-wheeling, all-inclusive fashion that intoxicates with every note.
The musical signature owes much to the diversity of the five-piece band, fronted by the eponymous and exotic Rupa Marya, along with the intensely woven but lightly worn reciprocity of their playing. As gently swaying piano accordion mingles with the pulse of a double bass, brass and percussion massage the senses with welcome hints of klezmer, Argentinean tango, French Musette and Roma music. All of this is subtly filtered into a seductively assembled whole.
There's a useful tension, too, between Marya's ambition to say something politically relevant and her aspiration to do so in an determinedly laid-back style. You might catch echoes of DeVotchKa, The Tiger Lillies or Gogol Bordello here but you won't find any of their unfettered hysteria, comic-book grotesquerie or messy rawness. If you absolutely insist on a comparison, think Pink Martini with the emphasis on music rather than on style for style's sake.
Instead, there's something sunlit, warm and free to be found in all of this, and a refreshing honesty, too. It's musical globe-trotting conducted with sophisticated elegance and underpinned by a winning sense of joy.
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