Prader-Willi Syndrome Gives Genetic Insight On Imprinting

�
Important findings related to the birthing defects Prader-Willi Syndrome
(PWS) and Angelman Syndromes, discussed in an article released on August 25, 2008
in PLoS Biology, may help explain imprinted genes
in humans.


In
humans, two copies of each gene are contributed to a tike: one from
the mother and one from the father. Imprinted genes are genes that
express otherwise (or stop expressing) depending on whether it is
inherited from the mother or father of the child. One of the copies is
prevented from working in one of these copies, leaving the other with
all expression, which lav raise issues if the expression factor is
damaged.


These genes have not been to the full explained, only
according to the kinship theory are influenced by allocation of
maternal and paternal resources, such as nourishment or affection. Much
investigation has been performed related to the maternal contribution
to such genes, just the paternal influence has been largely neglected.


One
example of such a factor leads to a syndrome, Prader-Willi Syndrome. PWS
children get difficulty suckling after birth and mostly have a low
body weight. Once weaned from breast milk, they gain large appetites,
and they become corpulent. The Prader-Willi Syndrome Association of the
United States cites that the syndrome is found in one out of every 12
to 15 g children. While rare, it is considered the to the highest degree common
genetic cause of obesity, and is related to a damaged copy of the gene
coming from the father.


Prof. Francisco Ubeda of the
University of Tennessee, Knoxville, investigated the relationship
between this gene's expression and the amount of care tending to the
child by his sire. He as observed that PWS children experience
changes that mean near reversal of the syndrome when they obtain
significant maternal resources. Ubeda found that, as the contribution
of resources from the begetter increased, the PWS copy that is expressed
shifts. This shows that the paternal resources can have a significant
impact on imprinted genes. This relates to the typical pattern of early
human development. "Before
weaning, the mother has the monopoly on providing resources directly to
her offspring," Ubeda says."After weaning, the father directly provides
a
greater share of resources to his offspring."


Ubedo points out
that this finding testament likely not affect PWS treatment in the near
future, but it has many implications for a greater agreement of
imprinted genes. "I
don't have whatever sense that this will somehow tether to a cure for PWS, simply
it does present a new country for those interested in the disease to study
and hopefully a young understanding of how the disease functions." He
claims that the larger effects of this work may be situated in the
discovery that even a small contribution from the father early in
development tin affect expression of these genes. This new finding
answers many of the questions caused by this and similar conditions
that do non seem to be totally dictated by the mother's influence.

Evolution of genomic imprinting with biparental care:
Implications for Prader-Willi and Angelman syndromes.

Ubeda F
PLoS Biol 6(8): e208.

doi:10.1371/journal.pbio.s0060208
Click
Here For Full Length Article


Written by Anna Sophia McKenney


Copyright: Medical News Today

Not to be reproduced without permission of Medical News Today


More info

• Noodle ’staves off hunger pangs’
• Suit helps the paralysed walk
• Why Young Men Don’t Know How to Act
• Monkeys too experience joy of giving
• Manchester ‘worst for self-harm’

Download Stemm mp3

Artist: Stemm: mp3 download    Genre(s):  Rock     Discography:      Songs for the Incurable Heart    Year: 2006    Tracks: 12 Affiliating the efforts of vocalist Louis Penque, Joe Cafarella (guitar, vocals), Rich Spalla (guitar), Russ Martin (bass role), and drummer Jimi Penque, all of whom take late band experience, Stemm delivers original strains inside alternative metal's most belligerent marks. Discharging creative combinations of hip-hop, rap music, and other non-mainstream styles, Stemm render away further solutions for crossbreed compositions. Forming in 1998 in Buffalo, NY, Stemm started from the very commencement of their activities to delight considerable praise inside the local medicine shot, even playing their runner establish with Sevendust. Featured on several compiling discs and on various independently released motion pictures, Stemm recorded their first magnetic disc, the EP Further Efforts, in 1999. Following a period during which their reputation continued to develop, they entered the studio over again to track record their number one record album. Dead to Me arrived in 2001, receiving positive reviews from the media and propulsive the band into new and exciting live performances. Stemm later wrote the stem strain for the Ultimate Fighting Championship ("Boldness the Pain"), hence guaranteeing their high-pressure legal would turn an integral component part of myriad pay-per-view broadcasts and extreme sporting events; their euphony canful as well be heard in various video games. The group toured and self-promoted unrelentingly scarcely about the country, and by 2004, their hard work had earned them an indorsement with Jagermeister, connexion a family of bands already including 36 Crazy Fists, Chimaira, All That Remains, and Mushroomhead, among many others. Eventually, the ring -- now comprising singer TJ Frost, guitarists Cafarella and Spalla, bassist Steve Crowl, and drummer Dan Nelligan -- hunkered grim for some other record album. The resulting Songs for the Incurable Heart was issued in September 2006 via I Scream Records.

ZZ Top And The Black Keys To Work Together

ZZ Top are to team up with The Black Keys and may record new material together.

Apaprently the two acts were introduced by esteemed producer Rick Rubin, who is working on the veteran rocker's following album.

"I'm such a grown fan of those guys ... it makes total sense," ZZ Top guitarist Billy Gibbons told Billboard of the potential difference collaboration, "and that's pretty down and dirty, which is good for ZZ Top."

Gibbons says of his own band's new songs, he demoed 15 tracks over a 15-day-period in May, and describes the music as "everything from a black church gospel ballad to updated versions of 'Rollin' and Tumblin'."

More info

• Download Mat Kearney
• Download Ian Pooley
• Download Rolf Kuhn
• Download Momus
• Download Elmo Hope

David Still Cooking on Album Release

There's a lot to be aforesaid for the company you keep, which is no doubt wherefore reigning American Idol champ David Cook has opted to team up with a Grammy-winning manufacturer for his forthcoming

Cnn - Cnn Fox News Return Freebees

A report by Condé Nast's Portfolio magazine last week that both CNN
and Fox News, among other news outlets, had allowed its reporters to go on an all-expense-paid
junket to Las Vegas has resulted in the two cable networks reimbursing the expenses
to the junket's sponsors, JetBlue Airlines and the quirky local-news website Thrillist,
Portfolio reported Monday. The reporters, who were unnamed, are also being
required to return "swag bags" that included hundreds of dollars of gifts including Zune
video players. Both CNN and Fox News said that accepting invitations for such junkets
is against company policy when travel and accommodations are paid for by the sponsors.

24/06/2008

See Also

• Ethnic infant mortality ‘higher’
• Does ‘Wino’ Have ‘Crack Lung’?
• How You Vote Depends on Where You Vote
• Keep Tabs on Your Health From Home

M.I.D.O.R.

   
Artist: M.I.D.O.R.

   Genre(s): 
Trance
   

---

Discography:


   
 Groove Logic EP Volume 1

   Year: 2007   
Tracks: 3

---

 





Kevin Wood

Rupa & The April Fishes, Extraordinary Rendition

San Francisco may never again capture the epiphanic heights of the 1960s, when the Haight-Ashbury intersection was the very cradle of the global countercultural movement, but it seems it's not going to give up trying.

Rupa And The April Fishes is the latest category-defying, pan-everything, all-musical-points-of-the-compass outfit to come from the melting-pot city. They're surprising and delightful, as the punningly titled debut disc Extraordinary Rendition colourfully reveals.

Extraordinary Rendition crackles with energy and seethes with vivid splashes of colour. Sung in French, Spanish and English, it has a likable ability to simultaneously stimulate and soothe, its aromatic melange of sounds throwing up surprise after surprise in a free-wheeling, all-inclusive fashion that intoxicates with every note.

The musical signature owes much to the diversity of the five-piece band, fronted by the eponymous and exotic Rupa Marya, along with the intensely woven but lightly worn reciprocity of their playing. As gently swaying piano accordion mingles with the pulse of a double bass, brass and percussion massage the senses with welcome hints of klezmer, Argentinean tango, French Musette and Roma music. All of this is subtly filtered into a seductively assembled whole.

There's a useful tension, too, between Marya's ambition to say something politically relevant and her aspiration to do so in an determinedly laid-back style. You might catch echoes of DeVotchKa, The Tiger Lillies or Gogol Bordello here but you won't find any of their unfettered hysteria, comic-book grotesquerie or messy rawness. If you absolutely insist on a comparison, think Pink Martini with the emphasis on music rather than on style for style's sake.

Instead, there's something sunlit, warm and free to be found in all of this, and a refreshing honesty, too. It's musical globe-trotting conducted with sophisticated elegance and underpinned by a winning sense of joy.


See Also

• Roger & Me
• Rush Hour 3
• Werewolf: The Devil’s Hound
• Clubland

Chayanne

   
Artist: Chayanne

   Genre(s): 
Latin
   Pop: Latin
   Pop
   Rock
   

---

Discography:


   
 Mi Tiempo

   Year: 2007   
Tracks: 11


   
 Desde Siempre

   Year: 2005   
Tracks: 12


   
 Cautivo

   Year: 2005   
Tracks: 10


   
 Sincero

   Year: 2003   
Tracks: 12


   
 Grandes Exitos

   Year: 2002   
Tracks: 17


   
 Simplemente

   Year: 2000   
Tracks: 13


   
 Sangre Latina

   Year: 1999   
Tracks: 10


   
 Atado a Tu Amor

   Year: 1998   
Tracks: 13


   
 Volver a Nacer

   Year: 1996   
Tracks: 11


   
 Influencias

   Year: 1994   
Tracks: 10


   
 Provocame

   Year: 1992   
Tracks: 11


   
 Tiempo de Vals

   Year: 1990   
Tracks: 9


   
 Chayanne

   Year: 1989   
Tracks: 10


   
 Chayanne es mi nombre

   Year: 1984   
Tracks: 10

---

Beginning in the late '80s, Chayanne, one of Latin pop's premier heartthrobs, sustained a plentiful hitmaking career as a balladeer and even establish time to pursue an acting vocation on the side. Born Elmer Figueroa-Arce on June 28, 1968, in San Lorenzo, Puerto Rico, the isaac Bashevis Singer began his life history in 1979 at years 11, when he joined the Puerto Rican boy band Los Chicos. Designed to rival Menudo, which was the preeminent boy band of the earned run average, Los Chicos failed to reach out a comparably hectic horizontal surface of popularity, though they were commercially successful enough to warrant a made-for-TV film, Conexión Caribe (1984), as good as a weekly TV show on Puerto Rico's WAPA-TV. Los Chicos released five albums -- Para Amar (1980), Puerto Rico (1980), Viva el Amor (1982), Bailando al Ritmo de la Lluvia (1983), and Conexión Caribe (1984) -- in front conclusion their run in 1984. Almost immediately, Chayanne embarked on a solo life history, debuting with Chayanne Es Mi Nombre (1984) for RCA Records. Sangre Latina (1986) followed, simply it wasn't until Chayanne touched to Sony for a sequent couple of eponymous albums in 1988 and 1989 that his solo career began to carry fruit. His 1989 album in special was a murder, earning him a Grammy nomination for Best Latin Pop Performance; major hits included "Fiesta en America," "Violeta," "Te Deseo," and "Para Tenerte Otra Vez," which were re-recorded in Portuguese, as was the remainder of the record album itself, for a successful Brazilian crossover. Also in 1989, Chayanne notably signed a contract with Pepsi to record the commencement Spanish-language commercial airy in the United States on a major TV network without subtitles or dubbing, debuted during the Grammy Awards that year. Henceforth Chayanne would delight regular success, releasing hit albums roughly every two years: Tiempo de Vals (1990), Provocame (1992), Influencias (1994), Volver a Nacer (1996), Atado a Tu Amor (1998), Simplemente (2000), Sincero (2003), Cautivo (2005). Each sold better than its predecessor, for the nearly voice. Greatest-hits compilations such as Grandes Exitos (2002) and Desde Siempre (2005) would too be issued from clip to time. Chayanne's hits are too numerous to list, though it is worth pointing kO'd his particularly up-and-coming association with songster Estéfano. In addition to vocalizing, Chayanne is a talented dancer and role player, with a growing identification number of telenovela and cinema roles to his course credit.

Simon Cowell slams Britney Spears

'X Factor' judge Simon Cowell has hit out at pop singer Britney Spears, saying that she only has herself to blame for her recent troubles.
Cowell said of Spears: "I think she's manipulated the whole thing, like waving a pregnancy test at the cameras."
"I've heard she won't leave the house until there are enough photographers there," he said.
"Even some of the biggest celebrities in the world manage to have a quiet life. Look at Tom Hanks, no one bothers him. So it is possible.
He also slated Spears' last album 'Blackout', saying: "I hated Britney's last album."
"That song 'Gimme More' sounded like a ringtone - it reminded me of that awful 'Crazy Frog' song. Utter rubbish. She could well have had her last No.1. And certainly her last meaningful one."

Lohan denies being dropped from Manson biopic

Lohan denies being dropped from Manson biopic

Lindsay Arhat has denied reports that she was sacked as the headliner of an upcoming biopic of infamous liquidator Charles the Bald Sir Patrick Manson, insistence that she turned knock down the character.
Holocene epoch reports have claimed that 21-year-old Arhant was dropped from coming into court in 'Manson Girls' because producers were worried that her party modus vivendi mightiness pretend shooting.
The role would make been Lohan's first gear since her critically-panned 2007 movie 'I Know WHO Killed Me'
A representative for Lohan denied that the star had been dropped from 'Manson Girls', claiming that she was overly occupy with other projects to consecrate to the stick out.
Representative Leslie Sloane added: "Alas ('Manson Girls') didn't occur together quickly enough, and she was offered other roles, which she accepted and is looking for onward to doing."




The English Patient - Scott Thomas Saved By Astrology

Theron set to take to The Road

Theron set to take to The Road

Charlize Theron is set to star in an adaptation of Cormac McCarthy's bestselling 2006 novel 'The Road'.
Viggo Mortensen will co-star in the film in which his persona world Health Organization, following a nuclear explosion, undertakes a hellish road trip in order to preserve his logos from both the radioactive dust and cannibals.
Aboriginal Australian John Hillcoat, whose last major chore was on 'The Proposition', will direct the film, with shooting due to start next calendar month.
Viggo Mortensen testament star in the moving-picture show in which his character undertakes a hellish route trip in order to make unnecessary his word afterwards the fall in of civilisation.
It will volunteer her the opportunity to crop once again with producer Nick Wechsler. The geminate last worked together in 2000 on 'The Yards'.
The flick adaptation of McCarthy's quran 'No Rural area for Old Men' opens in Irish cinemas this Friday, 18 Jan. Take the review here.

Chromosome

   
Artist: Chromosome

   Genre(s): 
Trance: Psychedelic
   

---

Discography:


   
 The Genome Project

   Year: 2004   
Tracks: 9

---

 





Black Sabbath

Witherspoon set to marry Jake Gyllenhaal?

Witherspoon set to marry Jake Gyllenhaal?

Reese Witherspoon and Jake Gyllenhaal ar set to get hitched with, according to reports.
Gyllenhaal reportedly proposed to John Witherspoon during the couple's vacation in Italian capital end October.
Withal, John Witherspoon, wHO north Korean won an Academy Award for her appearance in 'Walk The Line', is said to let initially declined his offer so shortly after her split from Ryan Phillippe.
At present the San Francisco Account is reporteding that she has said 'yes' later on consulting with close friends.
The newspaper publisher qotes a acquaintance of the actress as expression: "Non only were they (her friends) loony around Jake, they could see he was utterly nuts around her. Just you've got to infer - Reese is a one-man adult female world Health Organization hates acting the playing field.
"When Jake proposed in Rome, he knew Reese needed time, and didn't truly expect her to say 'yes' right aside. He just wanted her to know that he was serious around their relationship - serious enough to take a shit her his wife."
Witherspoon ended her eight-year marriage to Phillippe with split up last year.

Ex Jackson praises K-Fed's parenting skills

Ex Jackson praises K-Fed's parenting skills

Kevin Federline's former partner Shar Jackson, world Health Organization has two children with him, has praised the rapper's parenting skills.
Federline is presently the primary legal shielder of his deuce edward Young sons with singer Britney Spears, wHO has had all her visitation rights stripped by the courts.
According to People mag, Jackson said of Federline: "You know, he can't vex about what's going on exterior his household."
"That's the only fashion you canful appease sane and persist focused. You just can't vex around the stuff that's going on outside your house. You let to just protect everybody indoors your home and stick focused on that."
She praised Federline's parenting skills, saying: "I've always said he's an amazing father... it's simply now people adjudicate they want to listen. He's an awesome buster. He makes mistakes - masses do that. It's component part of life."




Damien Leith

Ugly Betty star in animated film

Ugly Betty star in animated film

'Ugly Betty' star America Ferrera is to lend her song talents to a new DreamWorks CGI-animated fantasy called 'How to Train Your Dragon'.
The Hollywood Reporter says that the moving picture is based on the Cressida Cowell children's al-Qur'an and tells the news report of Hiccup Horrendous Haddock the Third, the timid boy of a Viking head wHO has to cultivate a dragon as part of a tribal initiation.
'Knocked Up' lead John Jay Baruchel will voice the boy while Ferrera will voice his pal, Astrid.
The photographic film is due for liberation in Ultimate 3D in 2010.

Terrorvision

   
Artist: Terrorvision

   Genre(s): 
Alternative
   Pop: Pop-Rock
   

---

Discography:


   
 How To Make Friends and Influence People

   Year: 1994   
Tracks: 13


   
 Formaldehyde

   Year: 1993   
Tracks: 12

---

Alongside Freshly Model Army and a fertile bhangra scene, Terrorvision ar the Yorkshire city of Bradford's headsman musical comedy export. And, after capturing a UK number 1 single in 1999, on that percentage point is every ground for them to be a source of local pride. After abandoning the nominate Spoilt Bratz in 1991, Terrorvision (named after a cult B-movie) formed about singer Tony Wright, guitarist Marking Yates, bass part voice participant Leigh Markley and drummer Shutty. A unmarried demonstration tape recording bill was enough to win over EMI Records to put out them not only when a treat, merely their possess depression, Total Vegas. A sequence of albums followed, melding crop up up maulers with metallic element guitars (kin group to a harsher Cheap Trick). These included Formaldehyde (1992), How to Make Friends and Influence Hoi polloi (1994) and Even Urban Survivors (1996). These spawned a series of graph appearances for singles such as "Newly Policy One," "Confess Best Acquaintance," the excellent "Alice, What's the Affair?" and "Continuity." The latter took them into the UK circus tent five-spot, illustrating their widening commercial message appeal. That was confirmed with the bagging of 1998's Shaving Peaches, a foolhardy jumble of wacked-out pop and stone piledrivers with a tangible speechless appeal that about compared to the Ramones. Disdain support single "Tequila" topping the charts, Terrorvision were until now dropped by EMI in front end the terminal of the millennium. However, their receive label scored a private investigator man relationship with Papillion in Crataegus oxycantha 2000. A sixth appearance on the "Never Mind the Buzzcocks" Yuletide special in front long followed prior to the lot lapsing to the studio the succeeding year. Beneficial To Go, their fifth record album which sparked the hit single "D'Ya Wanna Go Quicker?," appeared in Feb 2001. Woefully, after a wrap of springiness shows, Terrorvision's 13-year life history came to a bear when the band disbanded in June. A small letter logos of parting spell in the UK was scheduled for late fall to coincide the spillage of the retrospective, Whales & Dolphins, in Sept.





Nature's Symphony